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Historically, our knowledge of the use of Oregon grape (Mahonia aquifolium) came from First Nations peoples. Based on collected ethnographic information, we know that Native American tribes utilized all species of Oregon grape (Moerman, 2009). The Blackfoot, Karuk, Okanagan-Colville, Samish, Sanpoil, Squaxin and Thompson tribes utilized the roots and branches for addressing a variety of ailments. According to Moerman (2009), the Blackfoot and Sanpoil used a decoction of the roots as a gastrointe …